Mylène Jansen

80 Chapter 4 Amended Table 2 : Baseline characteristics of patients from the 2 randomized controlled trials KJD vs TKA KJD vs HTO KJD TKA (n=19) TKA (n=34) KJD HTO (n=20) HTO (n=41) Male sex, n (%) 8 (42) 12 (35) 15 (75) 24 (58) BMI (kg/m 2 ) 27.1 (3.8) 28.4 (6.0) 27.4 (3.3) 27.1 (3.3) Age (years) 55.7 (7.4) 55.4 (6.0) 51.2 (5.8) 49.3 (6.3) Axis (degrees) 2.1 (7.0) 2.8 (6.2) 5.9 (2.7) 6.1 (2.2) Kellgren-Lawrence grade, (median, IQR) - Grade 0, n (%) - Grade 1, n (%) - Grade 2, n (%) - Grade 3, n (%) - Grade 4, n (%) 4 (1.0) 0 (0) 0 (0) 1 (5) 8 (42) 10 (53) 3 (0.0) 0 (0) 0 (0) 7 (21) 21 (62) 6 (18) 3 (1.8) 0 (0) 5 (25) 4 (20) 10 (50) 1 (5) 3 (1.0) 1 (2) 4 (10) 11 (27) 21 (51) 4 (10) Flexion (degrees) 121 (10.5) 123 (7.7) 130 (7.2) 132 (8.5) Total WOMAC (0–100) 49.5 (10.8) 46.0 (12.4) 57.8 (17.8) 51.9 (17.0) Total KOOS (0–100) 38.4 (9.2) 35.8 (11.6) 45.7 (14.4) 40.6 (12.8) VAS pain (100 – 0) 68.2 (17.4) 72.6 (16.4) 52.5 (22.1) 64.4 (18.1) EQ-5D (0–1) 0.66 (0.25) 0.61 (0.24) 0.70 (0.20) 0.72 (0.18) ICOAP Combined (100 – 0) 46.4 (16.1) 56.8 (18.2) 46.2 (18.4) 50.0 (18.6) SF-36 PCS (0–100) 33.6 (9.0) 31.3 (7.2) 37.7 (6.7) 35.8 (8.1) SF-36 MCS (0–100) 54.5 (8.4) 54.0 (9.8) 55.0 (8.2) 55.1 (8.5) Minimum JSW, mm 0.65 (1.3) - 0.49 (0.7) 0.54 (1.0) Mean JSW, mm 1.93 (2.0) - 1.99 (1.5) 1.89 (1.2) Mean and standard deviation are given unless otherwise indicated. BMI: body mass index; EQ-5D: EuroQol-5D; HTO: high tibial osteotomy; ICOAP: Intermittent and Constant Osteoarthritis Pain score; IQR: interquartile range; JSW: joint space width; KJD HTO : KJD patients from the KJD versus HTO trial; KJD TKA : knee joint distraction patients from the KJD versus TKA trial; KOOS: Knee injury and Osteoarthritis Outcome Score; MSC: mental component scale; PCS: physical component scale; SF-36: Short Form 36; TKA: total knee arthroplasty; VAS: Visual Analogue Scale; WOMAC: Western Ontario and McMaster Universities Osteoarthritis Index. Amended Table 3 : Two-year changes in clinical and structural parameters KJD vs TKA KJD vs HTO KJD TKA (n=19) TKA (n=34) P- value KJD HTO (n=20) HTO (n=41) P- value WOMAC (0 – 100) Total 30.4 * (23.0 to 37.9) 42.4 * (38.1 to 46.8) 0.011 21.6 * (13.8 to 29.4) 29.2 * (23.6 to 34.8) 0.294 Stiffness 30.9 * (22.3 to 39.4) 34.4 * (27.2 to 41.6) 0.277 16.3 * (5.2 to 27.3) 24.8 * (18.2 to 31.4) 0.314 Pain 28.5 * (18.5 to 38.4) 45.4 * (39.6 to 51.2) 0.003 23.7 * (15.5 to 31.9) 31.9 * (25.4 to 38.3) 0.416 Function 31.0 * (23.0 to 38.9) 42.5 * (38.2 to 46.9) 0.033 21.6 * (13.7 to 29.6) 28.9 * (23.1 to 34.7) 0.319