Mylène Jansen

Two-year results of KJD compared with HTO and TKA 81 4 Amended Table 3 : Two-year changes in clinical and structural parameters ( continued ) KJD vs TKA KJD vs HTO KJD TKA (n=19) TKA (n=34) P- value KJD HTO (n=20) HTO (n=41) P- value KOOS (0–100) Total 28.7 * (20.4 to 37.1) 43.3 * (38.7 to 47.9) 0.002 21.6 * (14.4 to 28.8) 30.0 * (25.0 to 35.1) 0.109 Symptom 28.3 * (20.5 to 36.0) 33.6 * (27.5 to 39.6) 0.212 16.7 * (10.2 to 23.3) 22.6 * (17.7 to 27.5) 0.276 Pain 29.8 * (20.3 to 39.3) 47.9 * (42.3 to 53.5) 0.001 25.7 * (17.6 to 33.8) 32.5 * (27.0 to 38.1) 0.347 Function 31.0 * (23.0 to 38.9) 42.5 * (38.2 to 46.9) 0.034 21.6 * (13.6 to 29.6) 28.9 * (23.1 to 34.8) 0.317 Sport 28.3 * (14.6 to 42.0) 49.2 * (41.0 to 57.5) 0.007 25.7 * (15.1 to 36.3) 33.8 * (25.3 to 42.3) 0.314 QOL 26.3 * (13.7 to 38.8)* 44.5 * (36.4 to 52.6) 0.015 17.7 * (10.1 to 25.2) 32.2 * (25.4 to 39.0) 0.013 VAS (100 – 0) Pain -36.5 * (-49.8 to -23.2) -56.0 * (-64.8 to -47.3) 0.014 -21.8 * (-34.8 to -8.8) -38.4 * (-47.1 to -29.8) 0.269 EQ-5D (0–1) Index 0.10 (-0.02 to 0.22) 0.27 * (0.16 to 0.38) 0.023 0.16 * (0.06 to 0.26) 0.11 * (0.04 to 0.19) 0.564 ICOAP (100 – 0) Constant -33.0 * (-43.5 to -22.5) -48.8 * (-58.0 to -39.6) 0.109 -29.3 * (-39.6 to -19.0) -29.8 * (-38.5 to -21.0) 0.913 Inter -mittent -32.6 * (-44.0 to -21.3) -44.9 * (-52.4 to -37.5) 0.355 -25.3 * (-35.0 to -15.7) -31.9 * (-39.7 to -24.0) 0.559 Combined -32.8 * (-43.6 to -22.0) -45.6 * (-54.4 to -38.7) 0.216 -26.7 * (-36.3 to -17.1) -30.4 * (-37.7 to 23.1) 0.692 SF-36 (0–100) PCS 5.3 (-0.5 to 11.1) 17.9 * (14.6 to 21.2) <0.001 6.5 * (2.6 to 10.4) 11.9 * (8.9 to 14.9) 0.051 MCS 0.4 (-6.0 to 6.7) -0.6 (-6.6 to 5.3) 0.728 1.0 (-2.9 to 4.9) -1.1 (-4.5 to 2.3) 0.468 Flexion (deg) Knee - - - 1.4 (-2.3 to 5.0) -2.0 (-5.0 to 1.0) 0.254 JSW (mm) Minimum 0.90* (0.22 to 1.57) - - 0.94* (0.50 to 1.37) 0.62* (0.31 to 0.92) 0.233 Mean 0.99* (0.32 to 1.65) - - 0.83* (0.34 to 1.32) 0.88* (0.58 to 1.18) 0.884 Western Ontario and McMaster Universities Osteoarthritis index (WOMAC), Knee injury and Osteoarthritis Outcome Score (KOOS), Visual Analogue Scale (VAS), EuroQol (EQ)-5D, intermittent and constant osteoarthritis pain score (ICOAP), and Short Form (SF)-36 clinical scores and sub scores (PCS: Physical Component Score and MCS: Mental Component Score), maximum knee flexion and mean and minimum joint space width (JSW), for each of the 4 patient groups (total knee arthroplasty (TKA), knee joint distraction (KJD) patients indicated for TKA (KJD TKA ), high tibial osteotomy (HTO) and KJD patients indicated for HTO (KJD HTO ). Mean and 95% confidence intervals are given and ranges from worst to best are indicated for the clinical parameters. Statistically significant change ( p< 0.05) compared to baseline is indicated with *, calculated with paired t -tests. Changes between patient groups from each separate trial (KJD/TKA and KJD/HTO) are compared and corrected for baseline values using linear regression, bold p- values indicate statistical significance. Flexion parameters were not measured at 2 years in the KJD TKA and TKA groups.