Mylène Jansen

88 Chapter 5 EQ-5D. 27,28 The most important difference regarding morbidity was the high incidence of pin tract infections in the KJD group (59%) compared to 5% of wound infections in the HTO group. 27 While the authors discussed the possibility of undertaking knee-demanding activities after KJD, including recreational sports, they did not report actual RTS and RTW rates. Therefore, our aim was to compare RTS and RTW rates, including time to RTS and RTW, between these KJD and HTO patients who participated in the RCT. We hypothesized that KJD may lead to similar outcomes regarding participation in sport and work, and similar self-reported physical activity and work ability, compared to HTO. Methods Study design and patient selection We performed a survey among patients that were included in an RCT between 2011 and 2013, comparing KJD and HTO. 27 All patients of the RCT were eligible for inclusion in the present study, since they were <65 years of age at inclusion and thus of working age. The inclusion criteria for the original RCT comparing KJD and HTO were: medial tibiofemoral OA considered for HTO, normal range of motion (≥120° of knee flexion), BMI<35 kg/m 2 and normal stability. An overview of the inclusion- and exclusion criteria of the RCT can be found in the supplementary data (Supplementary Table S1). Of the included sample of 69 patients (23 KJDs and 46 HTOs), 2 KJD patients were excluded due to inoperability, 1 HTO patient was diagnosed with multiple sclerosis and could not complete follow-up, and 4 patients (2 KJD, 2 HTO) declared that they did not want to participate in follow-up studies (Figure 1). An online questionnaire was developed using an electronic data management system (Castor EDC, www.castoredc.com) . The remaining patients received an invitation by email between September and October 2017, followed by a maximum of 2 e-mail reminders. Institutional Review Board approval was obtained from the local medical ethical review board (reference number 17-538/C) prior to initiation of this study. The study was performed in accordance with the ethical principles from the Declaration of Helsinki and all patients gave written informed consent.