Mylène Jansen

Chapter 1 General introduction	9
Chapter 2 Knee joint distraction as treatment for osteoarthritis results in clinical and structural benefit: A systematic review and meta-analysis of the limited number of studies and patients available	19
Chapter 3 Initial tissue repair predicts long-term clinical success of knee joint distraction as treatment for knee osteoarthritis	45
Chapter 4 Knee joint distraction compared with high tibial osteotomy and total knee arthroplasty: Two-year clinical, radiographic, and biochemical marker outcomes of two randomized controlled trials	59
Chapter 5 Return to sport and work after randomization for knee distraction versus high tibial osteotomy: Is there a difference?	85
Chapter 6 Knee joint distraction in regular care for treatment of knee osteoarthritis: A comparison with clinical trial data	109
Chapter 7 User-friendliness of a novel dedicated knee joint distraction device: Experiences from clinical practice	129
Chapter 8 Reduction of pin tract infections during external fixation using cadexomer iodine	155
Chapter 9 Prospective one-year follow-up of clinical efficacy of knee distraction as treatment for knee osteoarthritis by use of the KneeReviver	167
Chapter 10 Joint distraction for osteoarthritis: Clinical evidence and molecular mechanisms	187
Chapter 11 Performance of Knee Image Digital Analysis of radiographs of patients with severe end-stage knee osteoarthritis	213
Chapter 12 Comparison between 2D radiographic weight-bearing joint space width and 3D MRI non-weight-bearing cartilage thickness measures in the knee using non-weight-bearing 2D and 3D CT as an intermediary	237
Chapter 13 Knee joint distraction results in MRI cartilage thickness increase up to ten years after treatment	253
Chapter 14 Changes in cartilage thickness and denuded bone area after knee joint distraction and high tibial osteotomy: Post-hoc analyses of two randomized controlled trials	275
Chapter 15 Cartilage collagen structure upon knee joint distraction and high tibial osteotomy as measured with T2-mapping MRI	301
Chapter 16 The molecular profile of synovial fluid changes upon joint distraction and is associated with clinical response in knee osteoarthritis	323
Chapter 17 Cartilage repair activity during joint-preserving treatment may be accompanied by osteophyte formation	351
Chapter 18 Exploring subchondral bone changes measured with CT after joint distraction treatment for end stage knee osteoarthritis	377
Chapter 19 Summary and general discussion	397
Nederlandse samenvatting	416
Dankwoord/acknowledgements	426
List of publications	430
List of conference abstracts	432
Curriculum vitae	434

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