Margriet Kwint

Chapter 5 102 To conclude, 3 different subgroups of GTV-volume change during treatment were identified with LCMM . In contrast with previous results, suggesting an association between GTV-change and overall survival, membership of a distinct subgroup of GTV-change during treatment did not result in different risks of outcomes whereas baseline GTV of the primary tumor was significantly associated with OS. Therefore, risk stratification at baseline might already be accurate enough in identifying the best treatment strategy for most patients. In patients with adenocarcinoma, and a steep decrease of GTV during treatment did show a tendency towards a worse OS.