Margriet Kwint

Chapter 2 46 Table S2.: Univariate Cox proportional hazards analysis for overall survival. HR (95% CI) P Reduction 0.63 (0.45, 0.88) 0.007 MLD 1.11 (1.06, 1.16) <0.001 Heart V 2 1.01 (1.00, 1.01) 0.002 Mean heart dose 1.04 (1.02, 1.06) <0.001 Oesophagus V 50 1.01 (1.00, 1.02) 0.016 Acute toxicity ≥G3 1.60 (1.08, 2.37) 0.019 Acute pulmonary toxicity ≥G3 10.03 (4.60, 21.88) <0.001 Acute dysphagia ≥G3 1.10 (0.68, 1.80) 0.694 Late toxicity ≥G3 1.32 (0.84, 2.10) 0.223 Late pulmonary toxicity ≥G3 1.78 (1.06, 2.98) 0.026 Late dysphagia ≥G3 0.83 (0.34, 2.02) 0.681 MLD=mean lung dose; Heart V2=volume of the heart receiving ≥2 Gy; Oesophagus V50 =volume of the heart receiving ≥50 Gy (EQD210); Pulmonary toxicity=cough, dyspnea and radiation pneumonitis.