Margriet Kwint

Table of Contents: 1 General introduction and outline of thesis 9 Part I Dose prescription and patient selection 2 Safety and efficacy of reduced dose and margins to involved lymph node metastases in locally advanced NSCLC patients. 25 3 Outcome of radical local treatment of non-small cell lung cancer patients with synchronous oligometastases. 49 Part II Image guided radiotherapy 4 Intra thoracic anatomical changes in lung cancer patients during the course of radiotherapy. 69 5 The prognostic value of volumetric changes of the primary tumor measured on Cone Beam-CT during radiotherapy for concurrent chemoradiation in NSCLC patients 85 Part III Acute esophagus toxicity 6 Acute esophagus toxicity in lung cancer patients after intensity modulated radiation therapy and concurrent chemotherapy. 113 7 The use of real-world evidence to audit NTCP- models for acute esophageal toxicity in non-small cell lung cancer patients 129 8 General discussion and future perspectives 147 Appendices 173 Summary 174 Nederlandse samenvatting 179 List of Publications 185 Dankwoord 188 Curriculum Vitae 193 PhD Portfolio 194