Margriet Kwint

Prognostic value of volumetric changes during concurrent chemoradiation 95 5 Table 2: Univariate andmultivariate Cox regression analysis for Overall Survival (OS), Progression Free Survival (PFS) and Local Regional Control (LRC). HR = Hazard Ratio, NOS = not otherwise specified, WHO PS: World Healthcare Organization Performance Score, GTV = Gross Tumor Volume, LCGM = Latent Class Growth Modelling. * GTV of the patients was ranked in 3 equal groups. Variable HR P-value HR P-value HR P-value HR P-value HR P-value OS uni OS multi PFS uni PFS multi LRC uni Sex Male 1.000 1.000 1.000 1.000 Female 0.695 0.003 0.790 0.063 0.850 0.198 0.895 0.561 Age ≤62 1.000 1.000 1.000 1.000 62< 0.638 0.001 1.560 0.001 1.216 0.118 1.320 0.145 WHO PS WHO PS 0 1.000 1.000 1.000 1.000 1.000 WHO PS 1 1.374 0.015 1.258 0.085 1.249 0.096 1.286 0.065 1.349 0.139 WHO PS 2 2.911 0.001 2.933 0.001 2.069 0.039 2.120 0.036 1.798 0.330 Pathology Adenoca 1.000 1.000 1.000 1.000 Squamousca 1.521 0.004 1.315 0.071 1.000 1.000 1.212 0.395 NSCLC NOS 1.130 0.414 1.085 0.592 0.932 0.644 0.845 0.479 Thoracic stage Stage I&II 1.000 1.000 1.000 Stage IIIA 1.346 0.272 1.238 0.433 0.888 0.741 Stage IIIB 1.526 0.123 1.514 0.132 1.164 0.676 T-stadium Tx-1 1.000 1.000 1.000 T2 1.095 0.619 1.421 0.069 2.026 0.019 T3 1.153 0.464 1.415 0.092 1.544 0.191 T4 1.251 0.208 1.316 0.157 1.466 0.220 N-stage N0-1 1.000 1.000 1.000 1.000 N2 1.256 0.147 1.274 0.141 1.412 0.040 1.036 0.878 N3 1.409 0.068 1.553 0.024 1.847 0.002 1.378 0.259 GTV primary* GTV-small 1.000 1.000 1.000 1.000 1.000 GTV-interme- diate 1.268 0.107 1.181 0.271 1.145 0.379 1.232 0.183 1.157 0.518 GTV-large 1.505 0.005 1.424 0.019 1.430 0.019 1.474 0.013 1.184 0.476 3 subgroup model LCMM Subgroup 1 1.000 1.000 1.000 Subgroup 2 1.111 0.592 1.131 0.555 1.188 0.626 Subgroup 3 1.020 0.934 0.950 0.839 0.810 0.649