Margriet Kwint

Chapter 5 96 Variable HR P-value HR P-value HR P-value HR P-value HR P-value OS uni OS multi PFS uni PFS multi LRC uni rel_GTV- first-last ≤median 1.000 1.000 1.000 >median 1.084 0.515 1.058 0.662 0.961 0.840 rel_GTV11- 21 ≤median 1.000 1.000 1.000 >median 1.231 0.163 1.142 0.438 1.010 0.967 Table 3: Univariate and multivariate Cox regression analysis for Overall Survival (OS) for the subgroup analysis (adenocarcinoma (AC), squamous cell carcinoma (SCC) and NSCLC- not otherwise specified (NOS)). HR = Hazard Ratio, WHO PS: World Healthcare Organization Performance Score, GTV = Gross Tumor Volume LCGM = Latent Class Growth Modelling. * GTV of the patients was ranked in 3 equal groups. Variable HR P-value HR P-value HR P-value HR P-value HR P-value HR P-value (OS AC) uni (OS AC) multi (OS SCC) uni (OS SCC) multi (OS NOS) uni (OS NOS) multi Sex Male 1.000 1.000 1.000 Female 0.740 0.168 0.786 0.280 0.714 0.111 Age ≤62 1.000 1.000 1.000 1.000 62< 1.421 0.110 1.745 0.008 1.860 0.004 1.349 0.148 WHO WHO PS 0 1.000 1.000 1.000 1.000 WHO PS 1 1.052 0.828 1.244 0.349 1.535 0.053 1.535 0.053 WHO PS 2 0.946 0.927 1.926 0.377 8.936 0.000 8.936 0.000 Stage Stage I&II 1.000 1.000 1.000 Stage IIIA 4.044 0.053 0.761 0.525 1.098 0.817 Stage IIIB 4.028 0.056 0.978 0.959 1.254 0.583 T-stage Tx-1 1.000 1.000 1.000 T2 0.963 0.899 0.851 0.661 1.219 0.519 T3 0.938 0.854 0.435 0.417 1.520 0.183 T4 0.913 0.782 0.998 0.996 1.267 0.417 N-stage N0-1 1.000 1.000 1.000 1.000 1.000 N2 2.467 0.025 2.467 0.025 1.078 0.749 1.081 0.739 1.212 0.466 N3 2.452 0.044 2.452 0.044 2.050 0.018 2.273 0.007 1.222 0.515 GTV primary* GTV-small 1.000 1.000 1.000 GTV-inter- mediate 1.028 0.917 1.151 0.604 1.282 0.336 GTV-large 1.260 0.389 1.453 0.184 1.407 0.161