Margriet Kwint

Prognostic value of volumetric changes during concurrent chemoradiation 97 5 Variable HR P-value HR P-value HR P-value HR P-value HR P-value HR P-value (OS AC) uni (OS AC) multi (OS SCC) uni (OS SCC) multi (OS NOS) uni (OS NOS) multi 3 subgroup model LCMM Subgroup 1 1.000 1.000 1.000 Subgroup 2 1.256 0.467 1.124 0.737 1.109 0.782 Subgroup 3 1.416 0.557 0.919 0.841 0.990 0.976 rel_GTV- first-last ≤median 1.000 1.000 1.000 >median 1.503 0.064 0.989 0.953 0.943 0.773 rel_GTV 11-21 ≤median 1.000 1.000 1.000 >median 1.794 0.110 1.577 0.338 1.311 0.471 ▲ Figure 1: Distinct relative tumor volume change trajectories during concurrent chemoradiation treatment for NSCLC patients identified with Latent Class Mixed Modelling. Subgroup 1 (red, N=327), subgroup 2 (green, N=39), subgroup 3 (black, N=28). Time=0 is the date of the RTplanning-CT and time =1 is the first date of the treatment. The GTV-change between time=0 and time =1 is the progression of the GTV between RTplanning-CT and start of treatment. The dashed lines show the 95%CI.