Margriet Kwint

1 General introduction and outline of thesis 9
2 Safety and efficacy of reduced dose and margins to involved lymph node metastases in locally advanced NSCLC patients. 25
3 Outcome of radical local treatment of non-small cell lung cancer patients with synchronous oligometastases. 49
4 Intra thoracic anatomical changes in lung cancer patients during the course of radiotherapy. 69
5 The prognostic value of volumetric changes of the primary tumor measured on Cone Beam-CT during radiotherapy for concurrent chemoradiation in NSCLC patients 85
6 Acute esophagus toxicity in lung cancer patients after intensity modulated radiation therapy and concurrent chemotherapy 113
7 The use of real-world evidence to audit NTCP- models for acute esophageal toxicity in non-small cell lung cancer patients 129
8 General discussion and future perspectives 147
Summary 174
Nederlandse samenvatting 179
List of Publications 185
Dankwoord 188
Curriculum Vitae 193
PhD Portfolio 194

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