Joeky Senders

191 Appendices ACKNOWLEDGEMENTS­ Mr. Dr. Broekman; dear Marike, none of this work would have been possible without your guidance. You are an inexhaustible source of bright ideas, always driven by the pursuit of curiosity. Your passion for research is highly contagious. Thanks for all the lessons you have taught me, inviting me to Boston, and mentoring me throughout my development as researcher and doctor. Prof. dr. Peul; dear Wilco, thanks for the opportunity to conduct my research in the context of a PhD program under your supervision. Your work has significantly impacted clinical care. Your ability to connect with people based on mutual empathy and respect inspires others and me to pursue the same. Dr. Gormley, Dr. Smith, Dr. Arnaout, and Dr. Zaidi; thanks for providing the academic environment, guidance, and trust to translate my curiosity in to scientific projects. Under your supervision, I have collaborated with a wide range of people with various expertise, yet all driven by the same intrinsic motivation. Dr. Staples and Dr. Mehrtash; dear Patrick and Alireza, thanks for introducing me to the world of data science and teaching me the R and python programming languages. Dr. Mekary, Hassan Dawood, David Cote, Aditya Karhade, Mark Zaki and Maya Harary and all other CNOC members; it was an absolute privilege to join this team of young bright minds. I learnt a wide range of skills simply by collaborating with all the talented people working at CNOC. Your willingness and enthusiasm to contribute to new ideas and projects constitutes the core of this highly productive research group. All my neurosurgical colleagues at University Medical Center Utrecht; thanks for providing the opportunity and creating the stimulating environment to train as a neurosurgical resident. Looking forward to further expand my neurosurgical exposure and experience in the years to come. Ivo Muskens and Enrico Martin; after countless Nero coffees and countless hours working side to side in the research lab, you both substantially contributed to the current thesis, as well as the unforgettable Boston experience accompanied with it. Rens Varkevisser, Yassine Ochen, Stijn van Roessel, Stijn de Jonge, Sjors Klompmaker, Sabine Egeler, Thomas Bodewes, Noortje Hagemeijer, Hannah Harp and Lauren Denholfe from the Appleton 88, as well as Sophia É, Claudia Bargon, Robin Tan, Valerie ter Wengel, Reinier de Vries, Luc Eijkelestam, Merel Stor, Sophie Zwanenburg,