Joeky Senders

Colophon Cover design: James Jardine | www.jamesjardine.nl Layout: James Jardine | www.jamesjardine.nl Print: Ridderprint | www.ridderprint.nl ISBN: 978-94-6416-509-8 Work performed at Leiden University Medical Center, Leiden University, and Brigham and Women’s Hospital, Harvard Medical School. Email: j.t.senders@gmail.com The research fellowship was supported by grants from: Michaël Fonds, Fundatie van Renswoude, Sint Geertruidsleen, Nijbakker-Morra Stichting and kfHeijn Fonds. Copyright © Joeky T. Senders, Amsterdam, The Netherlands. No part of this thesis may be reproduced, stored or transmitted in any form or by any means, without the prior permission of the author and the original copyright holder.