Joeky Senders

75 Thromboprophylaxis after craniotomy TABLE 1. Baseline characteristics compared by duration of postoperative thromboprophylaxis. Patient characteristic Definition 0-7 days LWMH (n = 166) 21 days LMWH (n = 135) p Mean age ± SD Years 56.5 ± 13.5 59.2 ± 12.7 0.09 Female gender – no. (%) 70 (42.2) 55 (40.7) 0.90 Mean BMI ± SD Kg/m 2 26.0 ± 4.8 26.07 ± 4.2 0.89 Histology – no. (%) AA 9 (5.4) 10 (7.4) 0.11 AOA 4 (2.4) 11 (8.1) AO 2 (1.2) 1 (0.7) GB 151 (91.0) 113 (83.7) WHO grade IV – no. (%) 151 (91.0) 113 (83.7) 0.08 IDH1 mutation – no. (%) 8 (7.1) 12 (13.6) 0.19 Median LOS [IQR] Days 8 [7-10] 7 [6-9] 0.006 Sub-total resection – no. (%) 68 (41.0) 99 (73.3) <0.001 Awake surgery – no. (%) 5 (3.1) 55 (42.3) <0.001 Median operative time [IQR] Min 190 [150-240] 165 [120-210] 0.001 Dexamethasone – no. (%) 148 (89.2) 132 (97.8) 0.007 KPS ≥ 70 – no. (%) 74 (88.1) 97 (82.9) 0.41 Immobility – no. (%) 14 (8.4) 8 (5.9) 0.54 History of VTE – no. (%) 0 (0) 3 (2.2) 0.18 History of malignancy – no. (%) 20 (12.2) 18 (13.3) 0.91 Radiotherapy – no. (%) 149 (91.4) 124 (91.9) 1.00 Chemotherapy – no. (%) 134 (82.2) 100 (74.1) 0.12 Abbreviations: AA=anaplastic astrocytoma; AO=anaplastic oligodendroglioma; AOA=anaplastic oligoastrocytoma; BMI=body mass index; GB=Glioblastoma; GTR=gross-total resection; IQR=inter-quartile range; KPS=Karnofsky performance scale; LMWH=low-molecular weight heparin; LOS=length-of-stay; no.=number; p=p-value; SD=standard deviation; WHO=World Health Organization; VTE=venous thromboembolism