Joeky Senders

76 Chapter 4 TABLE 2. Univariable and multivariable analysis for the outcome of VTE within 21 days. Univariable Analysis Patient characteristic Definition Total (n = 301) No VTE ≤ 21 days (n = 295) VTE ≤ 21 days (n = 6) p Mean age ± SD Years 57.7 ± 13.2 57.8 ± 13.2 56.8 ± 11.1 0.86 Female gender – no. (%) 125 (41.5) 121 (41.0) 4 (66.7) 0.40 Mean BMI ± SD Kg/m 2 26.0 ± 4.5 26.0 ± 4.5 25.5 ± 3.5 0.77 Histology – no. (%) AA 19 (6.3) 19 (6.4) 0 (0.0) 0.84 AOA 15 (5.0) 15 (5.1) 0 (0.0) AO 3 (1.0) 3 (1.0) 0 (0.0) GB 264 (87.7) 258 (87.5) 6 (100.0) WHO grade IV – no. (%) 264 (87.7) 258 (87.5) 6 (100.0) 0.77 IDH1 mutation – no. (%) 20 (10.0) 20 (10.1) 0 (0.0) 1.00 Median LOS [IQR] Days 7 [6-10] 7 [6-10] 13 [7-19] 0.37 Sub-total resection – no. (%) 167 (55.5) 164 (55.6) 3 (50.0) 1.00 Awake surgery – no. (%) 60 (20.8) 59 (20.8) 1 (16.7) 1.00 Median operative time [IQR] Min 180 [130-240] 180 [130-240] 190 [180-230] 0.50 21 days LMWH – no. (%) 135 (44.9) 131 (44.4) 4 (66.7) 0.50 Dexamethasone – no. (%) 280 (93.0) 275 (93.2) 5 (83.3) 0.90 KPS ≥ 70 – no. (%) 171 (85.1) 167 (85.2) 4 (80.0) 1.00 Immobility – no. (%) 22 (7.3) 20 (6.8) 2 (33.3) 0.09 History of VTE – no. (%) 3 (1.0) 3 (1.0) 0 (0.0) 1.00 History of malignancy – no. (%) 38 (12.7) 37 (12.6) 1 (16.7) 1.00 Multivariable Analysis Predictor OR 95% CI p Immobility 7.75 1.01 – 43.97 0.02 21 days LMWH 2.86 0.53 – 21.45 0.24 Abbreviations: AA=anaplastic astrocytoma; AO=anaplastic oligodendroglioma; AOA=anaplastic oligoastrocytoma; BMI=body mass index; GB=Glioblastoma; GTR=gross-total resection; IQR=inter-quartile range; KPS=Karnofsky performance scale; LMWH=Low-molecular weight heparin; LOS=length-of-stay; no.=number; OR=odds ratio; SD=standard deviation; WHO=World Health Organization; VTE=venous thromboembolism