Joeky Senders

77 Thromboprophylaxis after craniotomy TABLE 3. Univariable and multivariable analysis for the outcome of VTE within 90 days. Univariable Analysis Patient characteristic Definition Total (n = 301) No VTE ≤ 90 days (n = 281) VTE ≤ 90 days (n = 20) p Mean age ± SD Years 57.7 ± 13.2 57.6 ± 13.4 59.1 ± 9.4 0.61 Female gender – no. (%) 125 (41.5) 114 (40.6) 11 (5.0) 0.30 Mean BMI ± SD Kg/m 2 26.0 ± 4.5 25.9 ± 4.4 28.1 ± 5.8 0.04 Histology – no. (%) AA 19 (6.3) 19 (6.8) 0 (0.0) 0.39 AOA 15 (5.0) 15 (5.3) 0 (0.0) AO 3 (1.0) 3 (1.1) 0 (0.0) GB 264 (87.7) 244 (86.8) 20 (100.0) WHO grade IV – no. (%) 264 (87.7) 244 (86.8) 20 (100.0) 0.17 IDH1 mutation – no. (%) 20 (10.0) 20 (10.6) 0 (0.0) 0.49 Median LOS [IQR] Days 7 [6-10] 8 [6-10] 7 [6-8] 0.31 Sub-total resection – no. (%) 167 (55.5) 157 (55.9) 10 (50.0) 0.78 Awake surgery – no. (%) 60 (20.8) 56 (20.7) 4 (21.1) 1.00 Median operative time [IQR] Min 180 [130-240] 180 [120- 240] 180 [180-200] 0.80 21 days LMWH – no. (%) 135 (44.9) 123 (43.8) 12 (60.0) 0.24 Dexamethasone – no. (%) 280 (93.0) 261 (92.9) 19 (95.0) 1.00 KPS score ≥ 70 – no. (%) 171 (85.1) 158 (84.5) 13 (92.9) 0.65 Immobility – no. (%) 22 (7.3) 18 (6.4) 4 (20.0) 0.07 History of VTE – no. (%) 3 (1.0) 3 (1.1) 0 (0.0) 1.00 History of malignancy – no. (%) 38 (12.7) 36 (12.9) 2 (10.0) 0.98 Radiotherapy – no. (%) 273 (91.6) 254 (91.4) 19 (95.0) 0.88 Chemotherapy – no. (%) 234 (78.5) 216 (77.7) 18 (90.0) 0.31 Multivariable Analysis Predictor OR 95% CI p BMI per 5 Kg/m2 increase 1.66 1.08 – 1.83 0.02 WHO grade IV 6.88 0.87 – 890.69 0.07 Immobility 4.15 1.15 – 13.03 0.03 21 days LMWH 2.19 0.88 – 5.75 0.09 Abbreviations: AA=anaplastic astrocytoma; AO=anaplastic oligodendroglioma; AOA=anaplastic oligoastrocytoma; BMI=body mass index; GB=Glioblastoma; GTR=gross-total resection; IQR=inter-quartile range; KPS=Karnofsky performance scale; LMWH=low-molecular weight heparin; LOS=length-of-stay; no.=number; OR=odds ratio; SD=standard deviation; WHO=World Health Organization; VTE=venous thromboembolism.