Tamara van Donge

Personalized use of ibuprofen in preterm neonates 117 6 Supporting Information 3 - Figures 20 40 60 20 40 60 Population predictions (mg/L) Observed concentration (mg/L) 20 40 60 20 40 60 Individual predictions (mg/L) Observed concentration (mg/L) −2 0 2 0 20 40 Population predictions (mg/L) CWRESI −2 0 2 0 25 50 75 100 Time (h) CWRESI Figure S1 : Goodness-of-fit plots for PK model for S-ibuprofen, observed S-ibuprofen concentrations (mg/L) versus population predicted S-ibuprofen concentrations (mg/L) and versus individual predicted S-ibuprofen concentrations (mg/L). CWRESI: conditional weighted residual versus population predicted S-ibuprofen concentrations (mg/L) and versus time (h).