Tamara van Donge

Chapter 6 118 0 25 50 75 0 25 50 75 100 Time after first dose (h) S−ibuprofen concentration (mg/L) Observed Percentiles Median (lines) 95% CI (dotted lines) 5% 50% 95% Simulated Percentiles Median (lines) 95% CI (areas) 5% 50% 95% Figure S2: Prediction corrected visual predictive check for PK model for S-ibuprofen (mg/L) on y-axis and time after first dose (h) on x-axis. Observations are presented by black dots, and black lines illustrate observed percentiles. Shaded colored areas depict the simulated percentiles.