Tamara van Donge

Dynamics of creatinine in ELBW neonates 147 7 Supporting Information 3 Simulated creatinine and creatinine clearance A 0.5 0.7 0.9 1.1 1 7 14 21 28 35 42 Time after birth (days) Scr concentration (mg/dL) GA (weeks) 24 25 26 27 28 29 30 31 32 B 0.5 0.7 0.9 1.1 1 7 14 21 28 35 42 Time after birth (days) Scr concentration (mg/dL) GA (weeks) 24 25 26 27 28 29 30 31 32 Figure S1: Simulated serum creatinine (Scr) concentrations for typical ELBW neonates, stratified per gestational age (GA). Panel A: ELBW neonates delivered by C-section, panel B: ELBW neonates born by vaginal delivery. A 0.25 0.50 0.75 1 7 14 21 28 35 42 Time after birth (days) Creatinine clearance (ml/min) GA (weeks) 24 25 26 27 28 29 30 31 32 B 0.25 0.50 0.75 1 7 14 21 28 35 42 Time after birth (days) Creatinine clearance (ml/min) GA (weeks) 24 25 26 27 28 29 30 31 32 Figure S2: Simulated creatinine clearance for typical ELBW neonates, stratified per gestational age (GA). Panel A: ELBW neonates delivered by C-section, panel B: ELBW neonates born by vaginal delivery.