Tamara van Donge

Dynamics of creatinine in ELBW neonates 149 7 Supporting Information 4 Median [95% prediction interval] values for creatinine clearance per BSA Median [95% prediction interval] values for creatinine clearance (CrCL)per body surface area (BSA) for various postnatal days for three different typical individuals of 24, 27 and 32 weeks of gestation, retrieved from simulations (n=1000), Vd is based on median weight. BSA was determined with the formula of Ahn; BSA = 10.602 × weight 0.6561 / 10000 (BSA in m 2 and weight in g). Postnatal age 24 weeks GA 27 weeks GA 32 weeks GA Weight (g) CrCL (ml/min/1.73m 2 ) Weight (g) CrCL (ml/min/1.73m 2 ) Weight (g) CrCL (ml/min/1.73m2) Day 1 621 5.29 [3.25 – 8.99] 779 4.68 [2.87 – 8.02] 889 4.53 [2.70 – 7.73] Day 3 631 6.10 [3.54 – 10.34] 778 5.68 [3.23 – 9.36] 887 5.85 [3.25 – 9.37] Day 7 658 7.60 [4.13 – 11.97] 790 7.54 [3.94 – 11.64] 907 8.09 [4.25 – 12.09] Day 14 724 9.45 [4.97 – 14.08] 854 9.40 [5.26 – 13.89] 1000 9.83 [6.21 – 13.75] Day 21 795 10.35 [5.90 – 15.01] 935 10.30 [6.51 – 14.38] 1168 9.91 [6.99 – 13.31] Day 28 882 10.72 [6.80 – 14.95] 1053 10.31 [7.12 – 14.06] 1322 9.75 [7.11 – 12.52] Day 35 992 10.59 [7.19 – 14.51] 1205 9.98 [7.19 – 13.16] 1434 9.63 [7.18 – 12.07] Day 42 1132 10.17 [7.23 – 13.61] 1387 9.46 [6.91 – 12.14] 1513 9.52 [7.38 –11.75] 24 weeks GA 27 weeks GA 32 weeks GA 1 7 14 21 28 35 42 1 7 14 21 28 35 42 1 7 14 21 28 35 42 4 8 12 Time after birth (days) Creatinine clearance (ml/min/1.73m2)