Tamara van Donge

Chapter 10 202 20 30 40 50 ALB (g/L) 0.25 0.50 0.75 1.00 BTP (mg/L) 0.0 0.4 0.8 1.2 CYSC C (mg/L) 0 25 50 75 0−2 years 2−5 years 5−10 years 10−15 years Age (years) NGAL (µg/L) 0 1 2 3 B2M (mg/L) 20 40 60 80 SCR (µmol/L) 0 5000 10000 15000 20000 KIM−1 (ng/L) 0 100 200 300 400 0−2 years 2−5 years 5−10 years 10−15 years Age (years) URO (µg/L) Figure 1: Individual serum biomarker values represented per age group. Median values and interquartile ranges are presented by boxplots, and dots represent individual values for each biomarker. ALB: albumin, B2M: beta 2-microglobulin, BTP: beta-trace protein, SCR: creatinine, CYSC: cystatin C, KIM-1: kidney injury molecule-1, NGAL: neutrophil gelatinase-associated lipocalin, URO: uromodulin. For the primary analysis, no significant differences were observed when comparing URO values between the different age groups using ANOVA (Table S4). There were similarly no differences for KIM-1 and NGAL, and these results were the same using the non-parametric Kruskall-Wallis test for the untransformed measurements (Table 3).