Tamara van Donge

Reference intervals for kidney biomarkers in pediatrics 205 10 30 35 40 45 50 Albumin (g/L) 0 1 2 3 Beta 2−microglobulin (mg/L) 4 6 8 10 0 5 10 15 Age (years) log KIM1 (ng/L) 25 50 75 Creatinine (µmol/L) 0.25 0.50 0.75 1.00 Beta−trace protein (mg/L) 0.75 1.00 1.25 1.50 0 5 10 15 Age (years) Cystatin C (mg/L) sex female male Figure 2: Prediction reference intervals for age dependent kidney biomarkers. Lines represent the predicted mean concentration and shaded areas illustrate the 95% prediction reference intervals. Filled circles represent values included in statistical analysis, open circles represent outlier values (not included in statistical analysis).