Tamara van Donge

Reference intervals for kidney biomarkers in pediatrics 217 10 Table S4: Values for log transformed uromodulin concentrations (mean (SD), median (IQR) and minimum and maximum values). Group differences tested using parametric test (ANOVA). 0 – 2 years (N=20) 2 - 5 years (N=21) 5 - 10 years (N=35) 10 - 15 years (N=63) Uromodulin – log transformed, µg/L p-value 0.724 Mean (SD) 4.80 (0.588) 4.82 (0.552) 4.96 (0.626) 4.90 (0.569) Median (Q1, Q3) 4.72 (2.36, 5.24) 4.89 (4.54, 5.31) 5.06 (4.75, 5.29) 5.04 (4.63, 5.28) Min - max 3.86 - 5.96 3.20 - 5.51 2.60 - 5. 98 2.93 - 5.88 Table S5: Correlations of biomarker concentrations with age as continuous variable assessed by Pearson’s correlation coefficient. a log transformed values are used. Biomarker Pearson’s r p -value ALB, g/L 0.261 < 0.01 B2M, mg/L -0.276 < 0.01 BTP, mg/L -0.544 < 0.001 SCR, µmol/L a 0.864 < 0.001 KIM-1, ng/L a -0.217 < 0.05 CYSC, mg/L -0.135 0.129 NGAL, µg/L 0.032 0.709 URO, µg/L 0.016 0.852