Tamara van Donge

Efficacy and safety of amoxicillin in neonates 65 4 70% f T>MIC for enterococci (MIC 4 mg/L). Considering even higher MIC targets, such as the non-species-specific breakpoint of 8 mg/L, PTA ≥90% is only achieved for the modest target of 30% f T>MIC and falls off rapidly for higher PKPD targets (Figure 1). GBS L. monocytogenes Enterococci GBS L. monocytogenes Enterococci GBS L. monocytogenes Enterococci 25 mg/kg q6 50 mg/kg q12 100 mg/kg q12 0.25 0.5 1 2 4 8 16 25 50 75 100 25 50 75 100 25 50 75 100 Minimum inhibitory concentration (mg/L) Probability of target attainment (%) PKPD target 30% T>MIC 50% T>MIC 70% T>MIC 100% T>MIC Figure 1: Probability of target attainment (%) retrieved frommodel-based simulations following various dosing regimens which are not based on any demographic patient characteristics, assessed for multiple MICs breakpoints and PKPD targets (% f T>MIC). Dotted horizontal line indicates that ≥90% of population achieves PKPD target. GBS; Streptococcus agalactiae, MIC; minimal inhibitory concentration.