Tamara van Donge

Chapter 4 66 Table 2: Probability of target attainment (PTA) retrieved from model-based simulations following various dosing regimens, assessed for multiple MICs breakpoints and PKPD targets (%fT>MIC). Single dose (mg/kg) Dosing interval (hours) MIC 0.25 (mg/L) f T>MIC 30 % 50 % 70 % 100 % 100 4x % Swiss NICUs No demographic variables Center 4.1 25 6 100 99.9 99.4 83.1 73.4 Center 2,3,4.2 50 12 99.8 99.1 98.4 85.7 70.1 Center 6 100 12 99.8 99.8 99.6 85.9 76.9 Two demographic variables Center 5,8 25 12/8 99.9 98.9 97.5 77.6 56.1 Center 7,9 50 12/8 100 99.7 98.9 87 75 Center 1 50 12/8/6 99.9 99.6 98.8 84.1 70.4 International guidelines No demographic variables Lexicomp min , HL min 10 12 98.8 92.8 86.2 67.7 36.2 Lexicomp max , HL max 20 12 99.9 97.2 92.5 76.1 51.2 One demographic variable BNFC min 30/20 12/8 99.9 99.2 98 84.4 64.5 BNFC max 60/30 12/8 99.9 99.5 98.8 83.9 73.3 Swissmedic 50 12/8 99.9 99.4 98.2 84.8 69.9 NNF7 50 12/8/6 100 99.8 99 85 72.2 Shann 50 12/8/4 100 99.8 99.4 86.4 76.4 Grey and bold indicates ≥90% of the population achieves the PKPD target. White indicates <90% of the population achieves the PKPD target. MIC; minimal inhibitory concentration, fT>MIC; time above the MIC, HL; Harriet Lane 2014, BNFC; British National Formulary for Children 2015, NNF7; Neonatal Formulary 7 th edition, Shann; Frank Shann`s Drug Doses 2014. a indicates whether dosing regimen is are based on a patient characteristic (e.g. weight or gestational age).