Tamara van Donge

Efficacy and safety of amoxicillin in neonates 67 4 Probability of target attainment according to amoxicillin population PK model (Tang et al. ) MIC 1.0 (mg/L) f T>MIC MIC 4.0 (mg/L) f T>MIC MIC 8.0 (mg/L) f T>MIC 30 % 50 % 70 % 100 % 100 4x % 30 % 50 % 70 % 100 % 100 4x % 30 % 50 % 70 % 100 % 100 4x % 100 99.2 95.9 73.4 49.5 99.4 92.3 82.2 49.5 6.7 96.2 81.4 62.4 30.1 0.1 99.2 94.4 88 70.1 39.9 94.5 79.6 64.9 39.9 8 86.6 63.4 47.7 23.7 1 99.7 97.6 94.7 76.9 54 98 87.5 78.8 54 22.5 94.3 79.2 65.5 38.8 8 99.2 92.7 84.5 56.1 26.9 92 71.2 56.5 26.9 1.3 79.1 52.1 36.1 8.8 0 99.8 98 93.1 75 49.4 98.4 87.5 75.3 49.4 12.1 94.4 75.5 59.1 31.8 2.3 99.7 95.7 90.1 70.4 43.6 96.4 82.8 69.3 43.6 10.9 98.2 68.7 54.2 28.4 1.9 93 76.9 60.5 36.2 5.4 63.1 34.1 21.1 5.4 0 24.2 12 10.9 0.3 0 97.4 85.4 74.8 51.2 18.8 82.7 58.2 42 18.8 0.5 61.8 35 22.2 5.2 0 99.3 94.3 87 64.5 33.7 94 76.9 62 33.7 3.5 84.3 58.6 39.8 15.3 0.2 99.7 97.5 93.7 73.3 48.6 98 88.3 76.3 48.6 14.3 93.8 77.1 62.3 31.7 3.3 99.4 94.5 88.9 69.9 40.7 94.9 80.5 66.4 40.7 8.3 87.7 65.5 48.8 23.7 1.2 99.9 97.3 91.3 72.2 47.1 97.7 86.1 73.2 47.1 13.1 91.8 73.4 58.2 31 2.7 99.8 97.9 94.3 76.4 55.4 98.2 90.1 79.6 55.4 23.7 94.2 80 67 40.2 6.8