Tamara van Donge

Chapter 4 68 0 100 200 300 400 500 50 mg/kg q12/8/6 [C1] 50 mg/kg q12 [C2]# 25 mg/kg q6 [C4.1]# 25 mg/kg q12/8 [C5] 100 mg/kg q12 [C6]# 50 mg/kg q12/8 [C7] 25 mg/kg q12/8 [C8] 50 mg/kg q12/8 [C9] Swissmedic BNFc 2015.1 BNFc 2015.2 NNF7 2015 Shann 2014 Lexicomp.1 Lexicomp.2 Cmax amoxicillin (mg/L) 8 5.4 0.9 0 100 9.6 0 7.7 5.6 0.4 20.6 11.7 23.3 0 0 0 25 50 75 100 50 mg/kg q12/8/6 [C1] 50 mg/kg q12 [C2]# 25 mg/kg q6 [C4.1]# 25 mg/kg q12/8 [C5] 100 mg/kg q12 [C6]# 50 mg/kg q12/8 [C7] 25 mg/kg q12/8 [C8] 50 mg/kg q12/8 [C9] Swissmedic BNFc 2015.1 BNFc 2015.2 NNF7 2015 Shann 2014 Lexicomp.1 Lexicomp.2 Cmax amoxicillin > 140 mg/L (%) Figure 2: The maximum amoxicillin concentration levels (upper panel) and the percentage of patients exceeding a maximum amoxicillin concentration of 140 mg/L (lower panel) according to each of the Swiss national dosing regimens and the international guidelines. Diamond illustrates the mean maximum amoxicillin concentration per center. Dosing regimens discussed in Figure 1 are highlighted by #.