Tamara van Donge

Simplification of methadone dosing in preterm neonates 93 5 Supporting information 0 5 10 15 0 5 10 15 A Population predictions (mcg/L) Observations 0 5 10 15 0 5 10 15 Individual predictions (mcg/L) Observations B C −2 −1 0 1 2 3 4 5 1 2 3 4 5 6 Population predictions (mcg/L) Conditional weighted residuals w. interaction −2 −1 0 1 2 3 4 5 0 20 40 60 D Time after dose (hr) Conditional weighted residuals w. interaction Figure S1: Goodness-of-fit plots for final models for (R)- and (S)-methadone. (R)-methadone and (S)- methadone values are presented by blue and green circles, respectively. A; Observed concentrations versus population predicted concentrations. B; Observed concentrations versus individual predicted concentrations. C; Conditional weighted residuals with interaction (CWRESI) versus population predictions. D; Conditional weighted residuals with interaction versus time after dose.