Tamara van Donge

Chapter 5 94 25 50 75 100 Day 1 Day 2 Day 3 Day 4 Day 5 Day 6 Day 7 Days 0 − 8 Days 8 − 14 Days 14 − 21 Days 21 − 28 Time after adiminstration (days) Patients reaching target exposure (%) Dosing strategy Scenario 1a Scenario 1b Scenario 1c Scenario 2 Scenario 3 Scenario 4 Figure S2: Percentage of patients reaching target exposure of 985 mcg∙h/L according to different dosing scenarios represented in Table 2 of manuscript. Cumulative area under the curve is calculated for each day, until day seven and thereafter illustrated for four different time periods (e.g. week 1 to week 4).