Arjen Lindenholz

102 CHAPTER 4 Supplemental Table 2. SNRs and CNRs of the pre- and postcontrast scan variants 3 and 7 with the remaining comparisons Precontrast Postcontrast T 1W VIRTA T 1W VIRTA T 1W VIRTA T 1W VIRTA p-value** p-value** p-value* variant 3 E variant 7 variant 3 E variant 7 pre 3 – post 3 pre 7 – post 7 Any combination SNR tissue A 28.0 ± 1.8 40.5 ± 3.4 27.9 ± 1.3 42.4 ± 2.8 0.721 0.047 0,000 SNR carotid vessel wall B 15.3 ± 1.4 20.8 ± 2.7 17.2 ± 0.9 26.4 ± 4.0 0.009 0.005 0,000 SNR basilary vessel wall 13.0 ± 1.4 15.9 ± 1.7 13.4 ± 2.4 19.2 ± 1.8 0.241 0.017 0,000 SNR suprasellar CSF 9.1 ± 2.0 11.9 ± 2.2 11.3 ± 0.7 14.1 ± 2.4 0.005 0.047 0,000 SNR pontine CSF 5.9 ± 2.1 8.0 ± 2.0 6.5 ± 1.8 11.2 ± 2.6 0.114 0.009 0,000 SNR blood 3.6 ± 0.6 5.4 ± 1.2 3.8 ± 0.5 6.3 ± 1.4 0.508 0.047 0,000 SNR pituitary gland 23.0 ± 3.4 33.4 ± 4.7 33.3 ± 3.5 49.5 ± 6.7 0.005 0.005 0,000 CNR carotid vessel wall-CSF C 6.1 ± 1.6 9.0 ± 1.5 6.0 ± 0.7 12.3 ± 3.6 0.799 0.013 0,000 CNR basilary vessel wall-CSF D 7.2 ± 1.4 7.9 ± 1.4 7.0 ± 2.0 8.0 ± 1.9 0.878 0.878 0,279 CNR carotid vessel wall B -blood 11.6 ± 1.3 15.5 ± 2.9 13.5 ± 1.0 20.1 ± 3.8 0.005 0.007 0,000 Mean and standard deviations (expressed as mean ± SD) are calculated over 10 subjects. *A Friedman test was conducted to test for differences across the multiple vessel wall images. ** Post hoc analysis were performed using a Wilcoxon signed-rank test with Bonferroni correction applied to determine the specific differences between the variants. A. Tissue region of interest (ROI) is located at the left orbital gyri. B. The mean of the left and right distal intracranial internal carotid artery. C. Suprasellar CSF is used as reference. D. Pontine CSF is used as reference. E. Currently used in our clinic. VIRTA = volumetric isotropically reconstructed turbo spin echo acquisition, SNR = signal-to-noise ratio, CNR = contrast-to-noise ratio, CSF = cerebrospinal fluid, Bold = statistically significant (p < 0.008).