Arjen Lindenholz

121 Intracranial Atherosclerosis Assessed with 7T MRI 5 Risk factors for vessel wall lesions Associations between vascular risk factors and the number of vessel wall lesions in the anterior circulation are given as unadjusted and adjusted relative risks in Table 2 . After adjusting for age and sex, increasing age (adjusted only for sex) (RR, 1.02; 95% CI, 1.01-1.03; p-value < 0.001), diabetes mellitus (RR, 1.67; 95% CI, 1.20- 2.33; p-value 0.003), and hypertension (RR, 1.46; 95% CI, 1.06-2.02; p-value 0.02) were associated with a higher number of vessel wall lesions. The multivariable vascular risk score (SMART risk score, RR, 1.01; 95% CI, 1.00-1.02; p-value 0.004) was also associated with a higher number of vessel wall lesions in the anterior circulation. After Bonferroni correction, increasing age remained associated with a higher number of vessel wall lesions (p-value < 0.001). No association was found between smoking and the number of vessel wall lesions in the anterior circulation (RR, 1.00; 95% CI, 0.99-1.01; p-value 0.60). In the 83 participants who underwent both pre- and postcontrast vessel wall MRI, increasing age (RR, 1.03; 95% CI, 1.01-1.05; p-value 0.001) was associated with a higher number of enhancing vessel wall lesions in the anterior circulation, and this finding persisted after Bonferroni correction ( Table 3 ). Seven participants did not undergo postcontrast imaging because of either general discomfort, or nausea and/or dizziness with imaging or technical failure (catheter dislocation). In the 45 participants in whom both the anterior and posterior circulation could be assessed, increasing age (RR, 1.02; 95% CI, 1.00-1.03; p-value 0.02), hypertension (RR, 1.49; 95% CI, 1.01-2.21; p-value 0.046), diabetes mellitus (RR, 1.78; 95% CI, 1.37-2.32; p-value < 0.001), higher systolic blood pressure (RR, 1.15; 95% CI 1.06- 1.25; p-value 0.001), and lower eGFR (RR, 1.01; 95% CI 1.00-1.02; p-value 0.004) were associated with a higher number of vessel wall lesions, after adjusting for age and sex ( Table 4 ). After Bonferroni correction, a higher systolic blood pressure (p-value 0.001) and diabetes mellitus (p-value < 0.001) remained associated with a higher number of vessel wall lesions. Again, we did not find an association between smoking and the total number of vessel wall lesions (RR, 0.99; 95% CI 0.98-1.01; p-value 0.87).