Arjen Lindenholz

123 Intracranial Atherosclerosis Assessed with 7T MRI 5 Table 3. Associations between vascular risk factors and the anterior enhancing vessel wall lesions Risk factor Unadjusted relative risk (±95%CI) P-value Adjusted relative risk (±95%CI) P-value Age (per year increase) 1.03 (1.01-1.05) 0.001 1.03 (1.01-1.05)* 0.001 Sex (male) 0.84 (0.49-1.41) 0.50 0.71 (0.42-1.20)** 0.20 Body mass index (per 1-point increase) 0.99 (0.95-1.05) † 0.98 0.99 (0.95-1.04) † 0.99 Systolic blood pressure (per 10 mmHg) 1.07 (0.95-1.19) 0.26 1.03 (0.92-1.15) 0.59 Hypertension (presence) 1.73 (1.04-2.89) 0.04 1.49 (0.88-2.52) 0.13 LDL (per mmol/L increase) 1.09 (0.87-1.36) ‡ 0.48 1.12 (0.91-1.39) ‡ 0.29 HDL (per mmol/L increase) 0.90 (0.30-2.70) § 0.85 0.72 (0.26-1.97) § 0.52 Triglycerides (per mmol/L increase) 1.14 (0.81-1.61) § 0.44 1.11 (0.78-1.58) § 0.57 Hyperlipidemia (presence) 1.78 (1.07-3.00) 0.03 1.39 (0.80-2.39) 0.24 Diabetes mellitus (presence) 1.97 (1.21-3.20) 0.006 1.53 (0.91-2.57) 0.11 eGFR (in mL/min) 1.00 (0.99-1.01) 0.73 1.01 (1.00-1.02) 0.13 Smoking status (per pack year) 1.00 (0.98-1.01) 0.53 1.00 (0.98-1.01) 0.73 Vascular risk score (SMART, per %) 1.01 (1.00-1.02) 0.11 NA Table 3. Eighty-tree participants were included in this analysis. Seven of the 90 participants did not receive a contrast agent (because of catheter failure or discomfort) and were excluded for this analysis. The unadjusted and adjusted (for age and sex) relative risks including their 95% confidence intervals (CI) for the total number of anterior contrast-enhancing vessel wall lesions. A p-value < 0.05 was considered a trend; a p-value < 0.0013 (the Bonferroni correction) was considered indicative of a statistically significant difference. eGFR, estimated glomerular filtration rate; HDL, high density lipoprotein; LDL, low density lipoprotein; NA, not applicable; SMART, Second manifestations of arterial disease that estimates the 10-year risk for recurrent vascular event in patients with manifest cardiovascular disease. *, Adjusted for sex only; **, adjusted for age only; †, obtained in 82 participants; ‡, obtained in 70 participants; §, obtained in 72 participants.