Arjen Lindenholz

30 CHAPTER 2 Figure 5 . Perivascular Spaces and Lacunar Infarcts. An example of a juxtacortical, enlarged perivascular space (PVS) mimicking a cerebral microinfarct (CMI), in a post-mortem brain of a 68-year-old female with Alzheimer’s Disease pathology (BB VI) and severe cerebral amyloid angiopathy, identified on ( A ) T2- weighted ex vivo MR-imaging (repetition time 3500 ms, echo time 164 ms, acquired voxel size 0.4 × 0.4 × 0.4 mm 3 , no SENSE acceleration, scan duration 112 minutes) and with ( B ) histopathological correlation, Hematoxylin&Eosin (H&E) staining. ( A ) The small hyperintense enlarged PVS is located in juxtaposition to the cortex (white arrow). ( B ) No evidence of neuronal death or gliosis is seen on H&E (black arrow). (images courtesy of S.J. van Veluw). Figure 6 . Cerebellar cortical infarct cavity on 7T post-mortem MRI. Cerebellar cortical infarct cavity (white arrow) in the left cerebellar hemisphere on T2-weighted 7T post-mortem MRI; 3D TSE; TR 3000 ms; TE 207 ms; reduced focusing angle of 40°; acquired voxel size 0.70 × 0.70 × 0.70 mm 3 ; matrix size 284 × 169; FOV 200 × 119 x 120 mm 3 ; SENSE: 2 × 2; scan duration 8 minutes 39 seconds. The cavity and the surroundings of the cerebellum are black due to Fomblin, a proton-free fluid without MR signal. Notice the sharp demarcation of the cavity and surrounding hyperintense gliosis (white arrow) from the intact subjacent white matter (black arrows), which proved to be characteristic imaging features of cerebellar cortical infarct cavities and enabled the translation to clinical 1.5T MRI scans. 59,61