Matt Harmon

105 Chapter five Figure 1 . Physiology parameters over time in volunteers with endotoxemia and fever and volunteers with endotoxemia treated with induced normothermia. Lipopolysaccharide was given to all volunteers at T=0. Cooling to normothermia (37°C) was initiated at T=1 in the normothermia group. Dashed line indicates volunteers in the fever group. Solid line indicates volunteers in the normothermia group. Grey box represents the period of induced normothermia. Figure 1A-C: Dots represent means with bars representing standard deviation. Figure 1D: Dots represent medians with bars representing the interquartile ranges *P<0.05, ***P <0.0001, N.S. = Not significant. Abbreviations: BPM = beats per minute, LPS = lipopolysaccharide, MAP = mean arterial pressure, SIRS = systemic inflammatory response syndrome