Matt Harmon

109 Chapter five Figure 4 . Changes in cytokine profile in volunteers with endotoxemia and fever and volunteers with endotoxemia treated with induced normothermia. Figure 4A-C: Shows changes in cytokine profile in plasma from baseline over time. Lipopolysaccharide was given to all volunteers at T=0. Cooling to normothermia (37°C) was initiated at T=1 in the normothermia group. Dashed line indicates volunteers in the fever group. Solid line indicates volunteers in the normothermia group. Grey box represents the period of induced normothermia. Dots represent means with bars representing the standard deviation. Figure 4D-F: Boxplot showing the area under the curve of cytokine levels between the fever group (dark grey boxes) and normothermia group (light grey boxes). *P<0.05, N.S. = Not significant. Abbreviations: AUC = area under the curve, iL = interleukin, LPS = lipopolysaccharide, TNFa = tumor necrosis factor alpha