Matt Harmon

112 Chapter five References 1 Angus, D. C. & van der Poll, T. Severe sepsis and septic shock. The New England journal of medicine 369 , 2063, doi:10.1056/NEJMc1312359 (2013). 2 Evans, S. S., Repasky, E. A. & Fisher, D. T. Fever and the thermal regulation of immunity: the immune system feels the heat. Nat Rev Immunol 15 , 335-349, doi:10.1038/nri3843 (2015). 3 Hasday, J. D., Fairchild, K. D. & Shanholtz, C. The role of fever in the infected host. Microbes and infection / Institut Pasteur 2 , 1891-1904 (2000). 4 Schortgen, F. et al. Fever control using external cooling in septic shock: a randomized controlled trial. American journal of respiratory and critical care medicine 185 , 1088-1095, doi:10.1164/rccm.201110-1820OC (2012). 5 Schortgen, F. et al. Respective impact of lowering body temperature and heart rate on mortality in septic shock: mediation analysis of a randomized trial. Intensive care medicine 41 , 1800-1808, doi:10.1007/ s00134-015-3987-7 (2015). 6 Yang, Y. L. et al. Body temperature control in patients with refractory septic shock: too much may be harmful. Chin Med J (Engl) 126 , 1809-1813 (2013). 7 Gao, Y. et al. Effects of Target Temperature Management on the Outcome of Septic Patients with Fever. BioMed research international 2017 , 3906032, doi:10.1155/2017/3906032 (2017). 8 Morelli, A. et al. Effect of Heart Rate Control With Esmolol on Hemodynamic and Clinical Outcomes in Patients With Septic Shock: A Randomized Clinical Trial. JAMA : the journal of the American Medical Association 310 , 1683-1691, doi:10.1001/jama.2013.278477 (2013). 9 Poblete, B., Romand, J. A., Pichard, C., Konig, P. & Suter, P. M. Metabolic effects of i.v. propacetamol, metamizol or external cooling in critically ill febrile sedated patients. British journal of anaesthesia 78 , 123-127 (1997). 10 Lowry, S. F. Human endotoxemia: a model for mechanistic insight and therapeutic targeting. Shock 24 Suppl 1 , 94-100 (2005). 11 Lenhardt, R. et al. The effects of physical treatment on induced fever in humans. The American journal of medicine 106 , 550-555 (1999). 12 Delaunay, L. et al. Clonidine comparably decreases the thermoregulatory thresholds for vasoconstriction and shivering in humans. Anesthesiolog y 79 , 470-474 (1993). 13 Testori, C. et al. Surface cooling for induction of mild hypothermia in conscious healthy volunteers - a feasibility trial. Critical care 15 , R248-R248, doi:10.1186/cc10506 (2011). 14 Badjatia, N. et al. Metabolic impact of shivering during therapeutic temperature modulation: the Bedside Shivering Assessment Scale. Stroke; a journal of cerebral circulation 39 , 3242-3247, doi:10.1161/ STROKEAHA.108.523654 (2008). 15 Leon, K., Moisan, C., Amerand, A., Poupon, G. & L’Her, E. Effect of induced mild hypothermia on two pro-inflammatory cytokines and oxidative parameters during experimental acute sepsis. Redox Rep 18 , 120-126, doi:10.1179/1351000213Y.0000000049 (2013). 16 Kox, M. et al. Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans. Proceedings of the National Academy of Sciences of the United States of America 111 , 7379-7384, doi:10.1073/pnas.1322174111 (2014). 17 Morelli, A. et al. Microvascular Effects of Heart Rate Control With Esmolol in Patients With Septic Shock: A Pilot Study*. Crit Care Med 41 , 2162-2168, doi:10.1097/CCM.0b013e31828a678d (2013). 18 Zweifler, R. M., Voorhees, M. E., Mahmood, M. A. & Alday, D. D. Induction and maintenance of mild hypothermia by surface cooling in non-intubated subjects. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 12 , 237-243, doi:10.1016/j.jstrokecerebrovasdis.2003.09.006 (2003).