Matt Harmon

114 Chapter five Supplemental material Supplemental Table 1. In- and exclusion criteria. Inclusion criteria 1. Male 2. Age 18 – 35 years Exclusion criteria 1. No informed consent 2. Any abnormal test result during the screening prior to inclusion (medical history, physical examination, ECG, blood and urine examination). 3. History of drug abuse 4. Use of any medication on prescription 5. Smoking < 6 months 6. Participation in any other medical study < 3 months 7. Participation in previous volunteer studies using LPS Supplemental Table 2. Overview of mixed model results of individual physiological laboratory and calculated parameters comparing volunteers with endotoxemia and fever and volunteers with endotoxemia treated with induced normothermia (37°C). Variable Beta-coefficient 95% Confidence interval P-value Temperature °C -1.1 -1.4 - -0.8 <.0001 Heart rate (BPM) -22.8 -30.7 - -14.8 <.0001 Mean arterial pressure (mmHg) -6.7 -14.6 – 1.2 0.08 SIRS score * -0.5 -0.7 - -0.2 0.001 CRP (mg/mL) * -0.2 -0.5 - 0.0 0.08 Leukocytes (10E9/L) 1.4 -0.6 - 3.4 0.13 Lymphocytes (10E9/L) 0.3 0.1 - 0.6 0.007 pH -0.03 -0.06 - - 0.01 0.01 PCO2 (kPa) 0.4 0.0 - 0.9 0.05 Lactate (mmol/L) -0.3 -0.6 - 0.0 0.06 * Log transformed data. Abbreviations: BPM = beats per minute, CRP = C-reactive protein, SIRS = systemic inflammatory response syndrome