Matt Harmon

115 Chapter five Supplemental Table 3. Overview of different cytokine AUC levels between volunteers with endotoxemia and fever and volunteers with endotoxemia treated with induced normothermia (37°C). Fever (n=6) Normothermia (n=6) Variable Median [IQR] Median [IQR] P-value iL-6 AUC (pg/mL) 1841 [414 - 2252] 812 [62 - 1401] 0.4 TNFa AUC (pg/mL) -1012 [-1298 - -643] - 259 [-604 - -198] 0.5 iL-10 AUC (pg/mL) 242 [202 - 7383.6] 0 [-89 - 5.9] 0.04 Abbreviations: AUC = area under the curve, iL = interleukin, IQR = interquartile range, LPS = lipopolysaccharide, TNFa = tumor necrosis factor alpha Supplemental Figure 1 . Individual temperature plots of each healthy volunteer. Lipopolysaccharide was given to all volunteers at T=0. Cooling to normothermia (37°C) was initiated at T=1 in the normothermia group. Dashed line indicates volunteers in the fever group. Solid line indi- cates volunteers in the normothermia group. Grey box represents the period of induced normothermia.