Matt Harmon

12 Chapter one Figure 1 . Schematic overview of the pathogen induced febrile response in humans. PAMP’S Pyrogenic cytokines TNF, IL-6, IL-1B OVLT Hypothalamus PGE 2 Endocrine Metabolic Behavioral FEVER Cryogens Anti-inflammatory cytokines AVP TLR Abbreviations: AVP = arginine vasopressin; iL = interleukin; OVLT = organum vasculosum of the lamina terminalis; PAMPs = pathogen associated molecular patterns; PGE 2  = Prostaglandin E2; TLR = toll like receptors; TNF = tumor necrosis factor;