Matt Harmon

123 Chapter six Figure 1 . Conventional coagulation tests over time in volunteers with endotoxemia and fever and volunteers with endotoxemia treated with induced normothermia. Lipopolysaccharide was given to all volunteers at T=0. Cooling to normothermia (37°C) was initiated at T=1 in the normothermia group. Grey box represents the period of induced normothermia. The dashed line represents the fever group and the solid line represents the normothermia group. Figure 3A-E: Data are presented as means with standard deviation. Figure 3F: Data are presented as medians with interquartile range. *P<0.05, **P <0.01, N.S. = Not significant. Abbreviations: aPTT = activated Partial Thromboplastin Time. PT = prothrombin time. vWf Ag = von Willebrand factor Antigen