Matt Harmon

125 Chapter six Figure 3 . Clot formation and lysis parameters of rotational thromboelastometry (ROTEM) in volunteers with endotoxemia and fever and volunteers with endotoxemia treated with induced normothermia. Lipopolysaccharide was given to all volunteers at T=0. Cooling to normothermia (37°C) was initiated at T=1 in the normothermia group. Light grey box represents the period of normothermia. Dark grey box represents the reference range for specific ROTEM tests. The dashed line represents the fever group and the solid line represents the normothermia group. Data are presented as means with standard deviation. **P <0.01, N.S. = Not significant. Abbreviations: CT = clotting time. DIC = Disseminated intravascular coagulation. EXTEM = extrinsically activated test. ECA5-FCA5 = EXTEM clot amplitude after 5 minutes – fibrin-based extrinsically activated test (FIBTEM) clot amplitude after 5 minutes. INTEM = intrinsically activated test. MCF = Maximum clot firmness. ML = Maximum lysis.