Matt Harmon

128 Chapter six References 1 Angus, D. C. & van der Poll, T. Severe sepsis and septic shock. The New England journal of medicine 369 , 2063, doi:10.1056/NEJMc1312359 (2013). 2 Peres Bota, D., Lopes Ferreira, F., Melot, C. & Vincent, J. L. Body temperature alterations in the critically ill. Intensive care medicine 30 , 811-816, doi:10.1007/s00134-004-2166-z (2004). 3 Hasday, J. D., Fairchild, K. D. & Shanholtz, C. The role of fever in the infected host. Microbes and infection / Institut Pasteur 2 , 1891-1904 (2000). 4 Schortgen, F. et al. Fever control using external cooling in septic shock: a randomized controlled trial. American journal of respiratory and critical care medicine 185 , 1088-1095, doi:10.1164/rccm.201110-1820OC (2012). 5 Gao, Y. et al. Effects of Target Temperature Management on the Outcome of Septic Patients with Fever. BioMed research international 2017 , 3906032, doi:10.1155/2017/3906032 (2017). 6 Polderman, K. H. Mechanisms of action, physiological effects, and complications of hypothermia. Crit Care Med 37 , S186-202, doi:10.1097/CCM.0b013e3181aa5241 (2009). 7 Raetz, C. R. et al. Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J 5 , 2652-2660, doi:10.1096/fasebj.5.12.1916089 (1991). 8 Elin, R. J. et al. Properties of reference Escherichia coli endotoxin and its phthalylated derivative in humans. The Journal of infectious diseases 144 , 329-336, doi:10.1093/infdis/144.4.329 (1981). 9 Pernerstorfer, T. et al. Endotoxin-induced activation of the coagulation cascade in humans: effect of acetylsalicylic acid and acetaminophen. Arterioscler Thromb Vasc Biol 19 , 2517-2523, doi:10.1161/01. atv.19.10.2517 (1999). 10 Harmon, M. The effect of fever control on the inflammatory response in human endotoxemia. In preperation (2020). 11 Taura, P. et al. Clinical markers of the hypercoagulable state by rotational thrombelastometry in obese patients submitted to bariatric surgery. Surg Endosc 28 , 543-551, doi:10.1007/s00464-013-3203-1 (2014). 12 Bone, R. C. et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 101 , 1644-1655 (1992). 13 Wada, H. et al. Guidance for diagnosis and treatment of disseminated intravascular coagulation from harmonization of the recommendations from three guidelines. Journal of Thrombosis and Haemostasis 11 , 761-767, doi:10.1111/jth.12155 (2013). 14 Ostrowski, S. R. et al. Coagulopathy, catecholamines, and biomarkers of endothelial damage in experimental human endotoxemia and in patients with severe sepsis: a prospective study. Journal of critical care 28 , 586-596, doi:10.1016/j.jcrc.2013.04.010 (2013). 15 Reiter, R. et al. Regulation of protease-activated receptor 1 (PAR1) on platelets and responsiveness to thrombin receptor activating peptide (TRAP) during systemic inflammation in humans. Thromb Haemost 90 , 898-903, doi:10.1160/TH03-04-0245 (2003). 16 Schrottmaier, W. C. et al. Platelet activation at the onset of human endotoxemia is undetectable in vivo. Platelets 27 , 479-483, doi:10.3109/09537104.2015.1119814 (2016). 17 Gutmann, F. D., Murthy, V. S., Wojciechowski, M. T., Wurm, R. M. & Edzards, R. A. Transient pulmonary platelet sequestration during endotoxemia in dogs. Circ Shock 21 , 185-195 (1987). 18 Reitsma, P. H. et al. Procoagulant protein levels are differentially increased during human endotoxemia. J Thromb Haemost 1 , 1019-1023, doi:10.1046/j.1538-7836.2003.00237.x (2003). 19 Ruggeri, Z. M. The role of von Willebrand factor in thrombus formation. Thrombosis research 120 Suppl 1 , S5-9, doi:10.1016/j.thromres.2007.03.011 (2007).