Matt Harmon

129 Chapter six 20 Reininger, A. J. Function of von Willebrand factor in haemostasis and thrombosis. Haemophilia 14 Suppl 5 , 11-26, doi:10.1111/j.1365-2516.2008.01848.x (2008). 21 Muller, M. C., Meijers, J. C., Vroom, M. B. & Juffermans, N. P. Utility of thromboelastography and/ or thromboelastometry in adults with sepsis: a systematic review. Critical care 18 , R30, doi:10.1186/ cc13721 (2014). 22 Lier, H., Vorweg, M., Hanke, A. & Gorlinger, K. Thromboelastometry guided therapy of severe bleeding. Essener Runde algorithm. Hamostaseologie 33 , 51-61, doi:10.5482/HAMO-12-05-0011 (2013). 23 Muller, M. C. A., Meijers, J. C., van Meenen, D. M., Thachil, J. & Juffermans, N. P. Thromboelastometry in critically ill patients with disseminated intravascular coagulation. Blood Coagul Fibrinolysis 30 , 181-187, doi:10.1097/MBC.0000000000000808 (2019). 24 Shechter, M. Magnesium and cardiovascular system. Magnes Res 23 , 60-72, doi:10.1684/mrh.2010.0202 (2010). 25 Lu, L., Zhan, Y., Yu, J. & Sui, L. Prevalence of Thrombocytopenia and Its Association with Serum Magnesium. Biological trace element research 169 , 46-51, doi:10.1007/s12011-015-0406-4 (2016). 26 Lin, C. Y., Tsai, P. S., Hung, Y. C. & Huang, C. J. L-type calcium channels are involved in mediating the anti-inflammatory effects of magnesium sulphate. British journal of anaesthesia 104 , 44-51, doi:10.1093/bja/aep336 (2010). 27 Rochelson, B., Dowling, O., Schwartz, N. & Metz, C. N. Magnesium sulfate suppresses inflammatory responses by human umbilical vein endothelial cells (HuVECs) through the NFkappaB pathway. Journal of reproductive immunolog y 73 , 101-107, doi:10.1016/j.jri.2006.06.004 (2007). 28 Esen, F. et al. Effect of magnesium sulfate administration on blood-brain barrier in a rat model of intraperitoneal sepsis: a randomized controlled experimental study. Critical care 9 , R18-23, doi:10.1186/ cc3004 (2005). 29 Pinthong, D., Songsermsakul, P., Rattanachamnong, P. & Kendall, D. A. The effects of imidazoline agents on the aggregation of human platelets. J Pharm Pharmacol 56 , 213-220, doi:10.1211 /0022357022593 (2004 ). 30 Hsu, C. Y., Knapp, D. R. & Halushka, P. V. The effects of alpha adrenergic agents on human platelet aggregation. J Pharmacol Exp Ther 208 , 366-370 (1979). 31 Ganter, M. T. et al. The effect of clonidine on perioperative blood coagulation. J Clin Anesth 17 , 456- 462, doi:10.1016/j.jclinane.2004.11.004 (2005). 32 Flanders, C. A., Rocke, A. S., Edwardson, S. A., Baillie, J. K. & Walsh, T. S. The effect of dexmedetomidine and clonidine on the inflammatory response in critical illness: a systematic review of animal and human studies. Critical care 23 , 402, doi:10.1186/s13054-019-2690-4 (2019).

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