Matt Harmon

130 Chapter six Supplemental material Supplemental Table 1: Overview of results from the mixed effects models of conventional coagulation tests and derived coagulation abnormality scores comparing volunteers with endotoxemia and fever and volunteers with endotoxemia treated with induced normothermia (37°C). Variable Beta-coefficient 95% Confidence interval P-value Platelet count (109/L cells) 67.1 27.1 - 107.2 0.002 Fibrinogen (g/L) 0.1 -0.4 - 0.5 0.78 D-dimer (mg/L) -0.3 -0.7 - 0.0 0.06* vWf (%) -89.2 -171.7 - -6.6 0.03 aPTT (sec) 2.7 0.9 - 4.5 0.005 PT (sec) 0.0 -0.8 - 0.8 0.99 G-value (dynes/cm2) 1.1 -0.6 - 2.7 0.15 DIC-score -0.3 -0.6 - 0.0 0.04* * Log transformed data. Abbreviations: aPTT= activated partial thromboplastin time, DIC= disseminated intravascular coagulation, vWf= von Willebrand factor