Matt Harmon

131 Chapter six Supplemental Table 2: Overview of results from the mixed effects model analyses of the rotational thromboelastometry (ROTEM) tests comparing volunteers with endotoxemia and fever and volunteers with endotoxemia treated with induced normothermia (37°C). EXTEM INTEM FIBTEM Subtest b 95% CI P-value b 95% CI P-value b 95% CI P-value Coagulation time (sec) 6.4 -13.0 - 25.6 0.47 43.9 13.0 – 74.8 0.007 22.5 -8.3 – 53.0 0.15 Maximum clot firmness (mm) 4.8 -2.0 - 11.6 0.13 9.7 -1.1 - 20.4 0.06 4.74 -2.0 - 11.4 0.13 Amplitude 5 minutes (mm) 5.1 -1.5 - 11.7 0.10 7.14 -2.2 - 16.5 0.11 3.07 -1.9 - 8.0 0.18 Amplitude 10 minutes (mm) 4.1 -3.2 - 11.3 0.22 8.1 -2.9 - 19.1 0.12 4.29 -1.7 - 10.2 0.13 Maximum lysis (%) 0.7 -3.8 - 5.1 0.73 0.1 -5.7 - 5.9 0.96 0.16 -0.5 - 0.8 0.35* EXTEM amplitude 5 minutes – FIBTEM amplitude 5 minutes (mm) - - - - - - 0.1 -0.2 – 0.4 0.38 * Log transformed data. Abbreviations: CI = confidence interval. EXTEM = extrinsically activated test. FIBTEM = fibrin-based extrinsically activated test. INTEM = intrinsically activated test, IQR = interquartile range