Matt Harmon

141 Chapter seven Table 2. Mechanical ventilation parameters and blood gas values at the end of targeted temperature management (T=28 hours) in survivors at 28-days vs. non-survivors at 28-days Variable (no. of patients) All N=567 Survivors N= 328 Non-survivors N= 239 P-value Tidal volume (mL/kg PBW) (n=492) 7.7 (6.4-8.7) 7,8 (6.5-8.7) 7,52 (6.4-8.7) 0.247 PEEP (cmH 2 O) (n=489) 6 (5-8) 6 (5-8) 7 (5-8) 0.372 Pplat (cmH 2 O) (n=325) 21.0 (18.0-24.0) 20.8 (18.0-24.0) 21.0 (18.0-25.0) 0.654 Respiratory rate (breaths/min) (n=535) 16 (14-20) 16 (13-18) 16.5 (15-20) <0.0001 Driving pressure (cmH 2 O) (n=300) 14.7 ±4.2 14.4 ±3.9 14.8 ±4.5 0.573 Power (J/min) (n=302) 6.1 (4.4-8.1) 6,1 (4.5-7.8) 6.1 (4.2-8.1) 0.916 Static compliance (mL/H 2 O) (n=302) 37.1 (29.2-47.1) 38.2 (31.5-48.8) 34.7 (27.4-44.7) 0.013 Respiratory minute volume (L/ min) (n=496) 9.3 ± 3.3 9.2 ±3.3 9.4 ±3.3 0.588 End tidal CO 2 (kPa) (n=307) 4.2 ±1.2 4.2 ±1.1 4.2 ±1.3 0.725 Alveolar dead space fraction (n=235) 0.20 ±0.25 0.21 ±0.18 0.19 ±0.31 0.567 PaCO 2 (kPa) (n=445) 5.3 ±0.9 5.3 ±0.9 5.3 ±1.0 0.351 PaO 2 (kPa) (n=442) 12.8 ±3.1 13.0 ±3.4 12.3 ±2.9 0.019 FIO 2 fraction (n=502) 0.35 (0.30-0.45) 0.35 (0.3-0.42) 0.35 (0.3-0.45) 0.342 P/F ratio (mmHg) (n=441) 267 ±93 274 ±89 256 ±98 0.052 pHa (n=444) 7.36 ±0.07 7.36 ±0.07 7.35 ±0.09 0.051 Lactate (mmol/L) (n=401) 1.4 (1.0-2.1) 1.2 (0.9-1.8) 1.7 (1.1-2.7) <0.0001 Base excess (mEq/L) ( n=442) -3.0 ±3.8 -2.5 ±3.4 -3.6 ±4.4 0.005 Abbreviations: PEEP, positive end-expiratory pressure, Pplat = plateau pressure of the respiratory system, P/F ratio, PaO 2 /FIO 2 ratio Data is presented as mean ± standard deviation or median (interquartile range)