Matt Harmon

150 Chapter seven References 1 Scirica, B. M. Therapeutic hypothermia after cardiac arrest. Circulation 127 , 244-250, doi:10.1161/ CIRCULATIONAHA.111.076851 (2013). 2 Network, T. A. R. D. S. Ventilation with Lower Tidal Volumes as Compared with Traditional Tidal Volumes for Acute Lung Injury and the Acute Respiratory Distress Syndrome. New England Journal of Medicine 342 , 1301-1308, doi:doi:10.1056/NEJM200005043421801 (2000). 3 Determann, R. M. et al. Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial. Critical care 14 , R1, doi:10.1186/cc8230 (2010). 4 Serpa Neto, A. et al. Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respiratory distress syndrome: a meta-analysis. JAMA : the journal of the American Medical Association 308 , 1651-1659, doi:10.1001/jama.2012.13730 (2012). 5 Asehnoune, K. et al. A multi-faceted strategy to reduce ventilation-associated mortality in brain- injured patients. The BI-VILI project: a nationwide quality improvement project. Intensive care medicine , doi:10.1007/s00134-017-4764-6 (2017). 6 Sutherasan, Y. et al. Management and outcome of mechanically ventilated patients after cardiac arrest. Critical care 19 , 215, doi:10.1186/s13054-015-0922-9 (2015). 7 Bellani, G. et al. Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA : the journal of the American Medical Association 315 , 788-800, doi:10.1001/jama.2016.0291 (2016). 8 Neto, A. S. et al. Epidemiological characteristics, practice of ventilation, and clinical outcome in patients at risk of acute respiratory distress syndrome in intensive care units from 16 countries (PRoVENT): an international, multicentre, prospective study. The Lancet Respiratory Medicine 4 , 882- 893, doi :http://doi.org/10.1016/S2213-2600 (16)30305-8 (2016). 9 Nielsen, N. et al. Targeted temperature management at 33 degrees C versus 36 degrees C after cardiac arrest. The New England journal of medicine 369 , 2197-2206, doi:10.1056/NEJMoa1310519 (2013). 10 Callaway, C. W. et al. Part 8: Post-Cardiac Arrest Care: 2015 American Heart Association Guidelines Update for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 132 , S465-482, doi:10.1161/cir.0000000000000262 (2015). 11 Deye, N. et al. Changes in cardiac arrest patients’ temperature management after the 2013 “TTM” trial: results from an international survey. Annals of intensive care 6 , 4, doi:10.1186/s13613-015-0104-6 (2016). 12 Aslami, H., Binnekade, J. M., Horn, J., Huissoon, S. & Juffermans, N. P. The effect of induced hypothermia on respiratory parameters in mechanically ventilated patients. Resuscitation 81 , 1723- 1725, doi:10.1016/j.resuscitation.2010.09.006 (2010). 13 Gattinoni , L. et al. Lung Recruitment in Patients with the Acute Respiratory Distress Syndrome. New England Journal of Medicine 354 , 1775-1786, doi:10.1056/NEJMoa052052 (2006). 14 Helmerhorst, H. J. et al. Effectiveness and Clinical Outcomes of a Two-Step Implementation of Conservative Oxygenation Targets in Critically Ill Patients: A Before and After Trial. Crit Care Med 44 , 554-563, doi:10.1097/ccm.0000000000001461 (2016). 15 Buuren, S. & Groothuis-Oudshoorn, K. mice: Multivariate imputation by chained equations in R. J Stat Softw 45 (2011). 16 Lenth, R. V. Least-Squares Means: The R Package lsmeans. J Stat Softw 69 , 1-33 (2016).