Matt Harmon

152 Chapter seven Supplemental material Supplemental Table 1. Multivariable regression for factors associated with 28-day mortality Variable OR 95%CI P-value Age (yr) 1.06 1.04 - 1.08 < 0.0001 SOFA 1.10 1.02 - 1.19 0.01 CA to ROSC (min) 1.02 1.01 - 1.03 < 0.0001 Respiratory rate (breaths/min) 1.09 1.04 - 1.13 < 0.0001 Abbreviations: CA, cardiac arrest. CI, confidence interval. OR, odds ratio ROSC, return of SOFA, sequential organ failure assessment. Supplemental Table 2. Mechanical ventilation parameters and blood gas values at the end of targeted temperature management (T=28 hours) in normoxemic patients (P/F ratio ≥ 200 mmHg) vs. hypoxemic patients (P/F ratio < 200 mmHg). Normoxemic N= 336 Hypoxemic N= 105 P-value Tidal volume (mL/kg PBW) 7.6(6.6-8.5) 8.0 (7-9) 0.022 PEEP (cmH 2 O) 5.2 (5-8) 8.0 (5-10) <0.0001 Pplat (cmH 2 O) 20.0 (17.9-23.0) 24.0 (20.8-26.4) <0.0001 Respiratory rate (breaths/min) 15 (13-18) 16 (15-20) 0.001 Driving pressure (cmH 2 O) 13.9±3.7 16.3 ±4.2 <0.0001 Static compliance (mL/H 2 O) 38.7 (32.8-48.4) 34.3 (27.2-41.4) 0.002 Respiratory minute volume (L/min) 8.8 ±2.8 9.8 ±3.1 0.005 etCO 2 (kPa) 4.3 ±1.2 4.0 ±0.8 0.035 Alveolar dead space fraction 0.18 ±0.26 0.26 ±0.18 0.01 PaCO 2 (kPa) 5.2 ±0.8 5.6 ±1.1 0.001 PaO 2 (kPa) 13.5 ±3.1 10.4 ±2.0 <0.0001 FIO 2 0.35 (0.3-0.4) 0.5 (0.45-0.6) <0.0001 P/F ratio (mmHg) 302 ±76 153 ±36 <0.0001 pHa 7.36 ±0.07 7.33 ±0.08 0.001 Lactate (mmol/L) 1.3 (0.9-1.9) 1.6 (1.1-2.7) 0.002 Base excess (mEq/L) -2.8 ±3.5 -3.6 ±4.3 0.126 Abbreviations: EtCO 2 , end tidal CO 2 . PEEP, positive end-expiratory pressure, P/F ratio, PaO2/FIO2 ratio. Data is presented as mean ± standard deviation or median (interquartile range) Abbreviations: PEEP. positive end-expiratory pressure