Matt Harmon

153 Chapter seven Supplemental Table 3. Mechanical ventilation parameters and blood gas values at the end of targeted temperature management (T=28 hours) in TTM33 vs. TTM36 TTM33 N= 281 TTM36 N= 286 P-value Tidal volume (mL/kg PBW) 7.7(6.5-8.7) 7.7 (6.4-8.7) 0.827 PEEP (cmH 2 O) 6 (5-8) 6 (5-8) 0.356 Pplat (cmH 2 O) 21 (18-25.0) 20 (18-24) 0.021 Respiratory rate (breaths/min) 16 (14-20) 16 (14-20) 0.588 Driving pressure (cmH 2 O) 15.0 ±4.3 14.1 ±4.3 0.102 Static compliance (mL/H 2 O) 35.9 (29.0-45.8) 37.5 (29.2-47.9) 0.368 Respiratory minute volume (L/min) 9.3 ±3.1 9.3 ±3.5 0.842 etCO 2 (kPa) 3.9 ±1.0 4.6 ±1.3 <0.0001 Alveolar dead space fraction 0.24 ±0.19 0.15 ±0.29 0.004 PaCO 2 (kPa) 5.3 ±0.9 5.3 ±0.9 0.513 PaO 2 (kPa) 12.6 ±3.1 12.9 ±3.2 0.238 FIO 2 0.35 (0.30-0.45) 0.35 (0.30-0.45) 0.572 P/F ratio (mmHg) 263 ±92 271 ±95 0.349 pHa 7.35 ±0.08 7.36 ±0.07 0.035 Lactate (mmol/L) 1.5 (1.1-2.7) 1.2 (0.9-1.9) <0.0001 Base excess (mEq/L) -3.6 ±4.1 -2.4 ±3.5 0.001 Abbreviations: EtCO 2 , end tidal CO 2 . PEEP, positive end-expiratory pressure, P/F ratio, PaO2/ FIO2 ratio. Data is presented as mean ± standard deviation or median (interquartile range) Abbreviations: PEEP. positive end-expiratory pressure Supplemental Table 4. Outcome Mixed model analysis between different target temperatures Β-coefficient 95%CI P-value PaCO 2 (kPa) -0.02 -0.14 - 0.09 0.68 EtCO 2 (kPa) 0.38 0.18 - 0.59 0.0003 Alveolar dead space fraction -0.07 -0.12 - -0.03 0.003 Respiratory minute volume (L/min) -0.13 -0.63 - 0.37 0.61 pHa 0.012 0.001 - 0.023 0.029 Lactate (mmol/L) -0.53 -0.84 - -0.21 0.001 Base excess (mEq/L) 0.75 0.20 - 1.31 0.008 Abbreviations: CI, confidence interval, etCO2, end tidal CO2