Matt Harmon

171 Chapter eight 18 Roberts, B. W., Kilgannon, J. H., Chansky, M. E. & Trzeciak, S. Association between initial prescribed minute ventilation and post-resuscitation partial pressure of arterial carbon dioxide in patients with post-cardiac arrest syndrome. Ann Intensive Care 4, 9, doi:10.1186/2110-5820-4-9 (2014). 19 Vannucci, R. C., Towfighi, J., Heitjan, D. F. & Brucklacher, R. M. Carbon dioxide protects the perinatal brain from hypoxic-ischemic damage: an experimental study in the immature rat. Pediatrics 95, 868-874 (1995). 20 Vaahersalo, J. et al. Arterial Blood Gas Tensions After Resuscitation From Out-of-Hospital Cardiac Arrest: Associations With Long-Term Neurological Outcome. Crit. Care Med., doi:10.1097/ CCM.0000000000000228 (2014). 21 Eastwood, G. M. et al. Targeted therapeutic mild hypercapnia after cardiac arrest: A phase II multi-centre randomised controlled trial (the CCC trial). Resuscitation 104, 83-90, doi:10.1016/j. resuscitation.2016.03.023 (2016). 22 Parke, R. L. et al. Co-enrolment for the TAME and TTM-2 trials: the cerebral option. Crit. Care Resusc. 19, 99-100 (2017). 23 Mattsson, N. et al. Serum tau and neurological outcome in cardiac arrest. Ann. Neurol. 82, 665-675, doi:10.1002/ana.25067 (2017). 24 Nielsen, N. et al. Targeted Temperature Management at 33 degrees C versus 36 degrees C after Cardiac Arrest. N. Engl. J. Med., doi:10.1056/NEJMoa1310519 (2013). 25 Jacobs, I. et al. Cardiac arrest and cardiopulmonary resuscitation outcome reports: update and simplification of the Utstein templates for resuscitation registries: a statement for healthcare professionals from a task force of the International Liaison Committee on Resuscitation (American Heart Association, European Resuscitation Council, Australian Resuscitation Council, New Zealand Resuscitation Council, Heart and Stroke Foundation of Canada, InterAmerican Heart Foundation, Resuscitation Councils of Southern Africa). Circulation 110, 3385-3397, doi:10.1161/01. cir.0000147236.85306.15 (2004). 26 Randomized clinical study of thiopental loading in comatose survivors of cardiac arrest. Brain Resuscitation Clinical Trial I Study Group. N. Engl. J. Med. 314, 397-403, doi:10.1056/ nejm198602133140701 (1986). 27 Jennett, B. & Bond, M. Assessment of outcome after severe brain damage. Lancet 1, 480-484 (1975). 28 Phelps, R., Dumas, F., Maynard, C., Silver, J. & Rea, T. Cerebral Performance Category and long- term prognosis following out-of-hospital cardiac arrest. Crit. Care Med. 41, 1252-1257, doi:10.1097/ CCM.0b013e31827ca975 (2013). 29 Blondin, N. A. & Greer, D. M. Neurologic prognosis in cardiac arrest patients treated with therapeutic hypothermia. Neurologist 17, 241-248, doi:10.1097/NRL.0b013e318224ee0e (2011). 30 van Buuren, S. & Groothuis-Oudshoorn, K. mice: Multivariate Imputation by Chained Equations in R. 2011 45, 67, doi:10.18637/jss.v045.i03 (2011). 31 Voicu, S. et al. Influence of alpha-Stat and pH-Stat Blood Gas Management Strategies on Cerebral Blood Flow and Oxygenation in Patients Treated With Therapeutic Hypothermia After Out- of-Hospital Cardiac Arrest: A Crossover Study*. Crit. Care Med. 42, 1849-1861, doi:10.1097/ ccm.0000000000000339 (2014). 32 Eastwood, G. M., Suzuki, S., Lluch, C., Schneider, A. G. & Bellomo, R. A pilot assessment of alpha- stat vs pH-stat arterial blood gas analysis after cardiac arrest. J. Crit. Care 30, 138-144, doi:10.1016/j. jcrc.2014.09.022 (2015). 33 Momiyama, Y. et al. Prognostic values of blood pH and lactate levels in patients resuscitated from out-of-hospital cardiac arrest. Acute Med Surg 4, 25-30, doi:10.1002/ams2.217 (2017). 34 Maupain, C. et al. The CAHP (Cardiac Arrest Hospital Prognosis) score: a tool for risk stratification after out-of-hospital cardiac arrest. Eur. Heart J. 37, 3222-3228, doi:10.1093/eurheartj/ehv556 (2016).